Role and mechanisms of autophagy in alcohol-induced liver injury

X Chao, WX Ding - Advances in Pharmacology, 2019 - Elsevier
Alcoholic liver disease (ALD) is one of the major causes of chronic liver disease worldwide.
Currently, no successful treatments are available for ALD. The pathogenesis of ALD is
characterized as simple steatosis, fibrosis, cirrhosis, alcoholic hepatitis (AH), and eventually
hepatocellular carcinoma (HCC). Autophagy is a highly conserved intracellular catabolic
process, which aims at recycling cellular components and removing damaged organelles in
response to starvation and stresses. Therefore, autophagy is considered as an important …