Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
BACKGROUND & AIMS: A recent genome-wide association study identified genetic
polymorphism (rs738409 C> G) in the PNPLA3/adiponutrin gene associated with liver
steatosis. This variant has also been linked to increased risk of alcoholic liver disease (ALD)
and cirrhosis in Mestizo Mexicans with excessive alcohol intake. Our aim was to study the
influence of this polymorphism on European Caucasian patients with histologically
suggestive ALD. METHODS: Three-hundred-and-twenty-eight healthy controls and 330 ALD …
polymorphism (rs738409 C> G) in the PNPLA3/adiponutrin gene associated with liver
steatosis. This variant has also been linked to increased risk of alcoholic liver disease (ALD)
and cirrhosis in Mestizo Mexicans with excessive alcohol intake. Our aim was to study the
influence of this polymorphism on European Caucasian patients with histologically
suggestive ALD. METHODS: Three-hundred-and-twenty-eight healthy controls and 330 ALD …