Type I interferons and endoplasmic reticulum stress in health and disease
J Sprooten, AD Garg - International review of cell and molecular biology, 2020 - Elsevier
Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed,
by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing
to this broad range of influence, type I IFNs also exhibit critical functions in many sterile
inflammatory diseases and immunopathologies, especially those associated with
endoplasmic reticulum (ER) stress-driven signaling pathways. Indeed, over the years
accumulating evidence has indicated that the presence of ER stress can influence the …
by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing
to this broad range of influence, type I IFNs also exhibit critical functions in many sterile
inflammatory diseases and immunopathologies, especially those associated with
endoplasmic reticulum (ER) stress-driven signaling pathways. Indeed, over the years
accumulating evidence has indicated that the presence of ER stress can influence the …