gp96 is a 96-kDa glycoprotein of the endoplasmic reticulum that is believed to be involved in
antigen processing as an intermediate carrier of peptides for presentation by major
histocompatibility complex (MHC) class I molecules. This function implies that gp96 carries a
large array of different peptides that represent the antigenicity of the cell and can serve all
MHC class I molecules. So far, the evidence regarding these peptides is largely indirect and
based on experiments where mice immunized with gp96 from tumor or virus-infected cells …