Importance The etiology of Kawasaki disease (KD) remains elusive, with immunologic and
epidemiologic data suggesting different triggers in individuals who are genetically
susceptible. KD remains the most common cause of acquired heart disease in pediatric
patients, and Japan is the country of highest incidence, with an increasing number of cases.
Objective To investigate whether an analysis of the epidemiologic KD record in Japan
stratified by age and prefecture (subregion) may yield new clues regarding mechanisms of …