Kawasaki disease presenting with hoarseness: a multinational study of the REKAMLATINA network

LB Gámez‐González, R Ulloa‐Gutierrez… - Pediatrics …, 2021 - Wiley Online Library
LB Gámez‐González, R Ulloa‐Gutierrez, C Murata, MA Yamazaki‐Nakashimada, E Kim…
Pediatrics International, 2021•Wiley Online Library
Background Recently, hoarseness affecting the supraglottic structure has been reported in
Kawasaki disease (KD). The objective of this study was to characterize the frequency of
hoarseness in acute KD patients in Latin America. Methods We used prospective data from
the multinational Red de Enfermedad de Kawasaki en America Latina (REKAMLATINA)
network. A total of 865 patients from 20 countries were enrolled during the 3 year study
period. Data on hoarseness were available in 858 (99.2%) patients. The clinical and …
Background
Recently, hoarseness affecting the supraglottic structure has been reported in Kawasaki disease (KD). The objective of this study was to characterize the frequency of hoarseness in acute KD patients in Latin America.
Methods
We used prospective data from the multinational Red de Enfermedad de Kawasaki en America Latina (REKAMLATINA) network. A total of 865 patients from 20 countries were enrolled during the 3 year study period. Data on hoarseness were available in 858 (99.2%) patients. The clinical and laboratory characteristics between hoarse and non‐hoarse KD were compared.
Results
Hoarseness was documented in 100 (11.6%) patients. Hoarse patients were younger than those with KD without hoarseness (median age 18 vs 26 months; P = 0.002) and presented with lower hemoglobin (10.7 g/dL vs 11.3 g/dL; P = 0.040) and hematocrit levels (32% vs 33%, P = 0.048).
Conclusions
Hoarseness was found to be prevalent as a presenting sign of acute KD in younger children. Anemia may indicate the presence of active inflammation.
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