BACKGROUND: Memory impairment is commonly associated with epilepsy, and the use of
antiepileptic drugs (AEDs) causes additional neuropsychologic deficits that are of particular
concern in learning-age children and elderly patients. The aim of this study was to
investigate hippocampal synaptic plasticity and morphology as well as hippocampal-
dependent memory in physiologic conditions and in a genetic model of epilepsy following
chronic treatment with the widely used AED valproic acid (VPA). METHODS: Mice lacking …