Effects of cPLA2 and its products. (a and b)
Tracings from single experiments. Alveolar or capillary routes of
TNF-α infusion are indicated. Replicated 4 times each.
(c) Group data for indicated inhibitors given in 10-minute alveolar
infusions before alveolar infusion of TNF-α; n
= 4 for each. AP < 0.05 vs.
baseline (open bar). BP < 0.05 vs.
TNF-α (solid bar). COCF3, AACOCF3; indo,
indomethacin; MK, MK886; WEB, WEB 2170BS. (d) Alveoli were
permeabilized by 10-minute saponin infusions. Then arachidonate was infused into
permeabilized (closed circles) and control (open circle) alveoli. Each point is
the mean ± SEM of 4 experiments. Line was drawn by linear regression
(P < 0.001).