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Identification and characterization of GDF6 as a driver of melanoma
In this episode, Craig Ceol, Arvind Venkatesan, and colleagues identify GDF6-mediated BMP signaling as a driver of melanoma and potential therapeutic target...
Published December 4, 2017
Increased cardiomyocyte proliferation benefit depends on the heart injury
Gerd Hasenfuß, Loren Field, and Karl Toischer demonstrate that enhancing cardiomyocyte regeneration is beneficial for some, but not all, forms of heart failure…
Published October 30, 2017
Human breast milk-derived commensal limits pathogenic inflammation
Mansour Mohamadzadeh and colleagues identify a commensal Propionibacterium in human breast milk that ameliorates intestinal inflammation...
Published September 25, 2017
Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Gou Young Koh, Jaeryung Kim, and Dae-Young Park discuss their work, which identifies angiopoietin/Tie2 as a critical pathway in maintaining the integrity and function of Schlemm’s canal…
Published September 18, 2017
Gene expression profile predicts response to pembrolizumab
In this episode, Terri McClanahan and Jared Lunceford identify a gene expression profile that correlates with a beneficial response to anti-PD-1 therapy
Published June 26, 2017
Neuropeptide FF acts on adipose tissue macrophages
Tamás Röszer and colleagues identify neuropeptide FF as an important player in the maintenance of healthy adipose tissue…
Published June 5, 2017
Characterizing the cells that underlie breast cancer recurrence
In this episode, Martin Jechlinger and colleagues show altered lipid metabolism and increased ROS production in residual breast cancer cells…
Published May 15, 2017
OX40 signals death for liver-resident immune cells
In this episode, Xian Li and colleagues demonstrate that stimulation of cell surface receptor OX40 induces pyroptosis in a liver-resident immune cell population.....
Published April 24, 2017
Unravelling differences in arthritis manifestation in mast cell-deficient mice
Peter Nigrovic and colleagues reveal that marrow and stromal context determine the role of mast cells in inflammation and that megakaryocytes can directly mediate inflammation...
Published April 4, 2017
Insight into lupus-associated CD11b mutations
In this episode, Marian Kaplan and Vineet Gupta reveal that lupus-associated mutations in the CD11b-encoding gene reduce CD11b function and that small molecule activation of CD11b ameliorates disease in mouse models of lupus...
Published April 3, 2017
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American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)
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